Gelsemine a natural indole alkaloid isolated from flowering plants of the genus Gelsemium with potent activity as an agonist of the mammalian glycine receptor, showing effect on pathways/systems related to xenobiotic- or diet-induced oxidative stress, and in the treatment of anxiety and other conditions.

Humantenmine is a natural toxic compound isolated and purified from the roots of Gelsemium elegans with potential inhibition of several CYP450 enzyme activities.

(Z)-Akuammidine is a potent μ-opioid agonist isolated and purified from the roots of Gelsemium elegans.

16-Epivoacarpine is a natural product isolated and purified from the herbs of Gelsemium elegans.

Gelsevirine, a natural product isolated and purified from the herbs of Gelsemium elegans with anxiolytic activity, may be via the agonist action of glycine receptor in the brain, and can significantly inhibit the proliferation of human carcinoma cell line SW480 and MGC80-3 in a dose-dependent manner, the 50% inhibiting concentration(IC50)of gelsevirine on SW480 cells and MGC80-3 cells are 1.41±0.06 mM and 1.22±0.11 mM respectively.

Humantenidine is a natural product isolated and purified from the herbs of Gelsemium sempervirens.