AS-1842856 is a potent inhibitor of forkhead box class O transcription factor 1 (Foxo1) with IC50 of 33 nM in HepG2 cells which directly bind to the active Foxo1.

JY-2是一种具有口服活性的FoxO1抑制剂，IC50为22 μM。JY-2对FoxO3a和FoxO4也有抑制作用。JY-2可用于糖尿病和银屑病的研究。