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(R)-CR8 is a cyclin dependent kinase (cdk) inhibitor with IC50 of 0.036 - 0.07 and 0.09 - 0.8 μM for cdk2 and cdk1,respectively.
HQ461 is a molecular glue degrader. It acts by promoting an interaction between CDK12 and DDB1-CUL4-RBX1 E3 ubiquitin ligase, leading to polyubiquitination and degradation of CDK12-interacting protein Cyclin K (CCNK).
dCeMM2 is a molecular glue degrader, inducing ubiquitination and degradation of cyclin K by prompting an interaction of CDK12:cyclin K with a CRL5B ligase complex.
dCeMM3 is a molecular glue degrader, inducing ubiquitination and degradation of cyclin K by prompting an interaction of CDK12:cyclin K with a CRL6B ligase complex.
dCeMM4 is a molecular glue degrader, inducing ubiquitination and degradation of cyclin K by prompting an interaction of CDK12:cyclin K with a CRL7B ligase complex.
Tags: Cyclin K/PROTAC | 分子胶 | Molecular Glue | Cyclin K/PROTAC 相关产品
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