Tetrahydroberberine is an isoquinoline alkaloid isolated and purified from the barks of Phellodendron chinense Schneid. It has micromolar affinity for dopamine D(2) (pK (i) = 6.08) and 5-HT(1A) (pK (i) = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors(5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4); pK (i) < 5.00).

Berberrubine, a natural product isolated and purified from the herbs of Coptis chinensis Franch. with antitumor and antidiabetic activity, dose-dependently inhibits IL-8 and MCP-1 protein levels in the media and mRNA expression of the cells stimulated with IL-1beta or TNF-alpha.

Groenlandicine是从黄连中分离得到的一种原小檗碱生物碱，具有中度抑制人类重组醛糖还原酶 (HRAR) 的作用，IC50值为154.2 μM，并能诱导拓扑异构酶I介导的DNA裂解。

Demethyleneberberine (DMB), a component of CPC, is reported to treat alcoholic liver disease as a novel natural mitochondria-targeted antioxidant.

Berbamine, a natural product isolated and purified from the roots of Cocculus orbiculatus (L.) DC., has high binding affinity toward the (GGA)8 G-quadruplex, and is a promising agent to suppress liver cancer growth by targeting CAMKII.

Berbamine dihydrochloride 是一种对多发性骨髓瘤具有显著疗效的NF-κB抑制剂。

8-Oxoepiberberine是口服左金方剂后血清中的一种主要生物碱代谢物，具有用于胃肠道疾病的研究潜力，尤其是在中药领域广泛应用于功能性胃肠疾病的基础研究中。

Picroside I, a natural product isolated and purified from the roots of Picrorhiza scrophulariiflora, possesses the properties of antioxidants,through the activity of superoxide dismutase, metal ion chelators and xanthine oxidase inhibitors.

Columbamine is a quaternary isoquinoline alkaloid isolated and purified from the roots of Coptis chinensis Franch, shows strong activity with IC50 48.1 µM and exerts anti-proliferative and anti-vasculogenic effects on metastatic human osteosarcoma U2OS cells with low toxicity.

Palmatine, a natural product isolated and purified from the rhizomes of Coptis chinensis Franch., is an inhibitor of dopamine generation. Palmatine could potentially be developed for the treatment of flavivirus infections.