MN58b is a CHKα inhibitor that inhibits phosphocholine synthesis and reduced cell growth through induction of apoptosis.

EB-3D is a novel potent and selective choline kinase ChoKα inhibitor with an IC50 of 1 μM. EB-3D induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells and induces senescence in breast cancer cell lines through the activation of the metabolic sensor AMPK and the subsequent dephosphorylation of mTORC1 downstream targets.

RSM-932A is an anticancer drug targeting the human choline kinase alpha, an enzyme involved in increased lipid metabolism of cancer cells.