BSJ-03-123 is a PROTAC selectively targeting on CDK6, consist of a warhead palbociclib (a CDK inhibitor) linked to a CRBN ligand pomalidomide.

THAL-SNS-032是一种选择性CDK降解剂，由CDK配体SNS-032、硼替佐米衍生物作为Cereblon E3连接酶（CRBN）的配体和连接物组成，形成一个PROTAC复合物。

CP5V is a PROTAC targeting on Cdc20 with DC50 value of 1.6μM, comprising a Cdc20 ligand and VHL binding moiety bridged by a PEG5 linker. It leads to significant inhibition of breast cancer cell proliferation and resensitization of Taxol-resistant cell lines and suppressed breast tumor progression in vivo.