Betulin caffeate is a natural product isolated and purified from the barks of Betula alba L., showing moderate antioxidant activity with IC50 value 108.0 ug/mL.

9,9'-Di-O-(E)-feruloylsecoisolariciresinol is a natural product isolated and purified from the herb of Betula ermanii, has significant cytotoxic activity against the DU145, LNCaP, and A549 cell lines, and is an inhibitor of mTOR signaling, have strong anticancer activity.