3,9-Dihydroeucomin, a natural product isolated and purified from the leaves of Agave sisalana Perrine ex Engelm. with immunomodulatory effects, shows inhibitory effects on PBMC proliferation activated by PHA with the IC(50) value of 19.4 mM.

Gitogenin, a natural product isolated and purified from the herbs of Agave americana, is a selective inhibitor of UGT1A4, and does not inhibit the activities of major human CYP isoforms. Gitogenin is also an inhibitor of enzyme α-glucosidase with IC50 values of 37.2±0.18 and 33.5±0.22 uM, respectively, and shows moderate stimulation of release activity on growth hormone from rat pituitary cells.

Spirostan-3-ol is a stereoisomer of sarsasapogenin, a steroid glycoside isolated from plant materials with potential anti-tumor activity via apoptosis.