Avasimibe is an ACAT inhibitor with IC50 of 3.3 μM, it also inhibits human P450 isoenzymes CYP2C9, CYP1A2 and CYP2C19 with IC50 of 2.9/13.9 and 26.5 μM, respectively.

Xanthohumol, a prenylated chalcone from hop, is an inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2 and shows chemopreventive effects.

Furan-2-carboxylic acid, a natural product isolated and purified from the herbs of Hexagonia speciosa with anti-bacterial effect, is also an orally active selective human cathepsin K inhibitor which may have the therapeutic potential for the treatment of diseases characterized by excessive bone loss including osteoporosis.

Mollugin, a natural product isolated and purified from the roots of Rubia cordifolia L., may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway.