XMD8-87是一种非受体酪氨酸激酶 2（TNK2）抑制剂，对 D163E 和 R806Q 突变体的 IC50 值分别为 38 nmol/L 和 113 nmol/L。

XMD16-5是一种 TNK2 抑制剂，IC50 值为 0.38µM，有效抑制固体肿瘤类型中 TNK2 截短突变的磷酸化。

AIM-100 is a potent and selective Ack1 (TNK2) inhibitor with IC50 value of 22nM, showing suppression phosphorylation of Tyr267 of the androgen receptor in prostate cancer cells.

KRCA-0008 is a potent and selective ALK/Ack1 inhibitor with IC50 of 12 nM/4 nM for ALK and Ack1 respectively and displays drug-like properties without hERG liability.