Disulfiram is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram acts as an allosteric inhibitor of MERS-CoV PLpro but as a competitive (or mixed) inhibitor of SARS-CoV PLpro. It also inhibits pyroptosis by blocking gasdermin D pore formation.

4-Diethylaminobenzaldehyde是一种可逆的醛脱氢酶 (ALDH) 抑制剂，对 ALDH1 的 Ki 值为 4 nM，并且表现出较强的抗雄激素活性，IC50 为 1.71 μM。