Tribendimidine 是一种广谱、口服活性的驱虫药，对 A. lumbricoides 和 N. americanus 具有特别高的活性。Tribendimidine 也是 L 型烟碱乙酰胆碱受体（nAChR）的激动剂。
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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Tribendimidine, an orally active, broad-spectrum anthelmintic agent, is particularly effective against A. lumbricoides and N. americanus. It also acts as an L-type nicotinic acetylcholine receptor (nAChR) agonist[1][2][3].
体内研究
Tribendimidine, administered orally in single doses of 75 and 150 mg/kg, inhibits C. sinensis in rats and effectively targets O. viverrini at 400 mg/kg in hamsters[2].
体外研究
Tribendimidine (100 μg/mL; 24 h) intoxicates C. elegans[3].
Tribendimidine, at concentrations ranging from 0 to 100 μg/mL over six days, exhibits toxicity with an LC50 of 54.4 μg/mL[3].
Tribendimidine-induced sterility at 0-200 μg/mL over 64 hours is resisted by trb mutant hermaphrodites, and Levamisole-resistant mutants also show resistance to it[3].
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