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产品名称 | AMPK ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
WZ4003 |
++++
NUAK1, IC50: 20 nM NUAK2, IC50: 100 nM |
98+% | |||||||||||||||||
Dorsomorphin |
++
AMPK, Ki: 109 nM |
99% | |||||||||||||||||
HTH-01-015 |
+++
NUAK1 , IC50: 100 nM |
99%+ | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | YLF-466D effectively stimulates AMPK, as indicated by phosphorylation at Thr172, and this activation correlates with its capacity to suppress aggregation induced by various agonists such as thrombin, ADP, and collagen. This suggests that YLF-466D's antiaggregatory effects are broad, affecting multiple pathways leading to platelet activation, rather than being specific to any single platelet-activating agent. These effects, including the inhibition of platelet aggregation, are observed to be concentration-dependent, reaching optimal efficacy at 150 μM. The IC50 values for the inhibition of aggregation induced by thrombin, ADP, and collagen are approximately 84, 55, and 87 μM, respectively[1]. |
体外研究 | YLF-466D effectively stimulates AMPK, as indicated by phosphorylation at Thr172, and this activation correlates with its capacity to suppress aggregation induced by various agonists such as thrombin, ADP, and collagen. This suggests that YLF-466D's antiaggregatory effects are broad, affecting multiple pathways leading to platelet activation, rather than being specific to any single platelet-activating agent. These effects, including the inhibition of platelet aggregation, are observed to be concentration-dependent, reaching optimal efficacy at 150 μM. The IC50 values for the inhibition of aggregation induced by thrombin, ADP, and collagen are approximately 84, 55, and 87 μM, respectively[1]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.15mL 0.43mL 0.21mL |
10.73mL 2.15mL 1.07mL |
21.46mL 4.29mL 2.15mL |
CAS号 | 1273323-67-3 |
分子式 | C29H20ClNO3 |
分子量 | 465.927 |
别名 | C24 |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(225.36 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |