Butylated hydroxytoluene is an antioxidant widely used in foods and in food-related products. Butylated hydroxytoluene is aFerroptosis inhibitor.
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HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
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Accessible (Haz class 3, 4, 5 or 8), International
Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Butylated hydroxytoluene, an antioxidant widely used in foods and food-related products, is a ferroptosis inhibitor which blocks lipid peroxidation[4]. In weanling rats, butylated hydroxytoluene had a greater deleterious effect on the growth of the male than of the female rat, especially at the 0.5% dietary level. At this level, it also increased the relative weight of the liver. The enlarged liver showed a marked elevation in the concentration of total lipids and of both total and esterified cholesterol. Moreover, there were striking increases in the plasma total and esterified cholesterol and phospholipid levels in the butylated hydroxytoluene treated animals[5]. As as a potent promoter of carcinogen, butylated hydroxytoluene (400 mg/kg; orally) administration increased the susceptibility of 7-week-old rasH2 mice to lung carcinogens[6].
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