产品说明书
Butylated hydroxytoluene
 |
同义名 : | BHT;NSC 6347 |
| CAS号 : | 128-37-0 | |
| 货号 : | A340728 | |
| 分子式 : | C15H24O | |
| 纯度 : | 98% | |
| 分子量 : | 220.351 | |
| MDL号 : | MFCD00011644 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 105 mg/mL(476.51 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 1 mg/mL(4.54 mM)，配合低频超声助溶 |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Butylated hydroxytoluene, an antioxidant widely used in foods and food-related products, is a ferroptosis inhibitor which blocks lipid peroxidation[4]. In weanling rats, butylated hydroxytoluene had a greater deleterious effect on the growth of the male than of the female rat, especially at the 0.5% dietary level. At this level, it also increased the relative weight of the liver. The enlarged liver showed a marked elevation in the concentration of total lipids and of both total and esterified cholesterol. Moreover, there were striking increases in the plasma total and esterified cholesterol and phospholipid levels in the butylated hydroxytoluene treated animals[5]. As as a potent promoter of carcinogen, butylated hydroxytoluene (400 mg/kg; orally) administration increased the susceptibility of 7-week-old rasH2 mice to lung carcinogens[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
4.54mL 0.91mL 0.45mL |
22.69mL 4.54mL 2.27mL |
45.38mL 9.08mL 4.54mL |
| 参考文献 |
|---|
|
[1]Babich H, et al. Butylated hydroxytoluene (BHT): a review. Environ Res. 1982 Oct;29(1):1-29. |