产品说明书

Dechloro Rivaroxaban

Print
Chemical Structure| 1415566-28-7 同义名 : -
CAS号 : 1415566-28-7
货号 : A994577
分子式 : C19H19N3O5S
纯度 : 95%
分子量 : 401.436
MDL号 : MFCD31654721
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(124.55 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Dechloro Rivaroxaban is an orally active, highly selective inhibitor of Factor Xa, effectively inhibiting human free FXa with a Ki of 0.4 nM. It also inhibits prothrombinase activity and fibrin-associated FXa activity with IC50s of 2.1 nM and 92 nM, respectively[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.49mL

0.50mL

0.25mL

12.46mL

2.49mL

1.25mL

24.91mL

4.98mL

2.49mL
参考文献

[1]Lang D, et al. In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans. Drug Metab Dispos. 2009 May;37(5):1046-55.