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Ro 5212773

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Chemical Structure| 1110781-88-8 同义名 : EPPTB
CAS号 : 1110781-88-8
货号 : A991869
分子式 : C20H21F3N2O2
纯度 : 95%
分子量 : 378.388
MDL号 : MFCD21605509
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(277.49 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Ro 5212773, also known as EPPTB, is a potent and selective TAAR1 antagonist (Ki=0.9 nM for mouse TAAR1) and has no significant effect on other TAARs[1][2].Ro 5212773 inhibits excitability of hippocampal pyramidal neurons and also reduces seizure-like events (SLE) and seizure activity[1].Ro 5212773 blocked TAAR1-mediated inwardly rectifying K+ current activation. Ro 5212773 effectively antagonised 1.5 μM β-phenylethylamine activation of cAMP production induced by TAAR1 in mice (IC50= 27.5 nM). The antagonistic effect of Ro 5212773 on cAMP production in mice was significantly stronger compared to TAAR1 in rat (IC50= 4539 nM) and human (IC50= 7487 nM)[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.64mL

0.53mL

0.26mL

13.21mL

2.64mL

1.32mL

26.43mL

5.29mL

2.64mL