(S)-Oxiracetam
产品说明书
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同义名 : | - |
| CAS号 : | 88929-35-5 | |
| 货号 : | A982800 | |
| 分子式 : | C6H10N2O3 | |
| 纯度 : | 98% | |
| 分子量 : | 158.155 | |
| MDL号 : | MFCD00242951 | |
| 存储条件： |
Pure form Sealed in dry,Room Temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 250 mg/mL(1580.73 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Oxiracetam is a cyclic derivative of γ-aminobutyric acid (GABA) which has been commonly used as nootropic drug to treat cognitive impairments[3]. ORC (Oxiracetam) suppressed the activation of BV2 cells, decreased the production of Aβ-induced inflammatory molecules and NO in BV2 cells, and protected HT22 cells against indirect toxicity mediated by Aβ-treated BV2 cell-conditioned medium[4]. ORC (100 mg/kg or 200 mg/kg) treatment significantly alleviated learning and memory deficits and neuronal damage in rats with VaD (vascular dementia)[5]. Moreover, oxiracetam at a dose of 800 mg/kg enhanced metabolism impaired by diaschisis in the caudal areas of the contralateral cortex[6]. NGF (nerve growth factor) in combination with oxiracetam is significantly effective in treating hypertensive cerebral hemorrhage as it can apparently recover neurologic impairment and limbs muscle force[7]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
6.32mL 1.26mL 0.63mL |
31.61mL 6.32mL 3.16mL |
63.23mL 12.65mL 6.32mL |
| 参考文献 |
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