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BAY 61-3606 2HCl

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Chemical Structure| 648903-57-5 同义名 : BAY-61-3606;BAY 61-3606 dihydrochloride
CAS号 : 648903-57-5
货号 : A974521
分子式 : C20H20Cl2N6O3
纯度 : 99+%
分子量 : 463.317
MDL号 : MFCD08276916
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 4 mg/mL(8.63 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
靶点

  • Syk

    Syk, Ki:7.5 nM
描述 BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.16mL

0.43mL

0.22mL

10.79mL

2.16mL

1.08mL

21.58mL

4.32mL

2.16mL
参考文献

[1]Kim SY, Park SE, et al. Bay 61-3606 Sensitizes TRAIL-Induced Apoptosis by Downregulating Mcl-1 in Breast Cancer Cells. PLoS One. 2015 Dec 31;10(12):e0146073.

[2]Yamamoto N, Takeshita K, et ak. The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c] pyrimidin-5-ylamino] nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents. J Pharmacol Exp Ther. 2003 Sep;306(3):1174-81.