产品说明书

6-Demethoxytangeretin

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Chemical Structure| 6601-66-7 同义名 : -
CAS号 : 6601-66-7
货号 : A958074
分子式 : C19H18O6
纯度 : 99%+
分子量 : 342.343
MDL号 : MFCD03427696
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(35.05 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 6-Demethoxytangeretin is a natural product isolated and purified from the herbs of Andrographis paniculata with anti-inflammatory activity. It also can suppress production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways and suppress the interleukin 1 (IL-1) induced production of proMMP-9/progelatinase B in rabbit synovial cells in a dose dependent manner (< 64 mM).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.92mL

0.58mL

0.29mL

14.61mL

2.92mL

1.46mL

29.21mL

5.84mL

2.92mL
参考文献

[1]Kim YM, Chae HS, et al. A citrus flavonoid, 6-demethoxytangeretin, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways. Biol Pharm Bull. 2014;37(5):871-6.

[2]Kimura J, Nemoto K, et al. 6-demethoxynobiletin, a nobiletin-analog citrus flavonoid, enhances extracellular signal-regulated kinase phosphorylation in PC12D cells. Biol Pharm Bull. 2013;36(10):1646-9.