产品说明书

E7820

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Chemical Structure| 289483-69-8 同义名 : ER68203-00
CAS号 : 289483-69-8
货号 : A950982
分子式 : C17H12N4O2S
纯度 : 99%+
分子量 : 336.368
MDL号 : MFCD09833234
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(312.16 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a unique angiogenesis inhibitor that suppresses the expression of the integrin alpha2 subunit on endothelial cells. It inhibits angiogenesis in rat aorta with an IC50 of 0.11 µg/ml and affects the expression of α-1, α-2, α-3, and α-5 integrin mRNA. E7820 displays antiangiogenic and antitumor activity[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.97mL

0.59mL

0.30mL

14.86mL

2.97mL

1.49mL

29.73mL

5.95mL

2.97mL
参考文献

[1]Funahashi Y, et al. Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. Cancer Res. 2002;62(21):6116-6123.

[2]Ito K, et al. Enhanced anti-angiogenic effect of E7820 in combination with erlotinib in epidermal growth factor receptor-tyrosine kinase inhibitor-resistant non-small-cell lung cancer xenograft models. Cancer Sci. 2014;105(8):1023-1031.