生物活性 | |||
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描述 | H-151 is a potent and selective STING antagonist. It dose-dependently abrogated IFNβ luciferase reporter at concentration ranging in 0.02-2μM in HEK293T cells. It reduced TBK1 phosphorylation (0.5μM, for 2h) in THP-1 cells and suppression of hsSTING palmitoylation (1μM, for 3h) without affecting respective controls. Pre-treatment of H-151 markedly reduced systemic cytokine responses in CMA (STING agonist)-treated mice[2]. | ||
作用机制 | H-151 can bind covalently with Cys91 of hsSTING.[2] |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
3.58mL 0.72mL 0.36mL |
17.90mL 3.58mL 1.79mL |
35.80mL 7.16mL 3.58mL |
参考文献 |
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