产品说明书

Masoprocol

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Chemical Structure| 27686-84-6 同义名 : meso-Nordihydroguaiaretic acid;meso-NDGA
CAS号 : 27686-84-6
货号 : A914482
分子式 : C18H22O4
纯度 : 98+%
分子量 : 302.365
MDL号 : MFCD00866548
存储条件:

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(347.26 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Masoprocol is an antineoplastic drug used to treat skin growths caused by sun exposure. A form of nordihydroguaiaretic acid that is taken by mouth is being studied in the treatment of prostate cancer.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00259818 Cancer Phase 1 Completed - United States, Arizona ... 展开 >> Premiere Oncology of Arizona Scottsdale, Arizona, United States United States, New York Albert Einstein College of Medicine Bronx, New York, United States United States, Tennessee Sarah Cannon Cancer Center Nashville, Tennessee, United States 收起 <<
NCT00664586 Refractory Solid Tumors ... 展开 >> Lymphoma 收起 << Phase 1 Terminated(Funding constraints... 展开 >>) 收起 << - United States, Tennessee ... 展开 >> The Sarah Cannon Cancer Center Nashville, Tennessee, United States, 37203 收起 <<
NCT00664677 Leukemias Acu... 展开 >>te Myeloid Leukemia (AML) Acute Lymphocytic Leukemia (ALL) Adult T Cell Leukemia (ATL) Chronic Myeloid Leukemia (CML-BP) Chronic Lymphocytic Leukemia (CLL) Myelodysplastic Syndrome (MDS) Chronic Myelomonocytic Leukemia (CMML) 收起 << Phase 1 Terminated(Funding constraints... 展开 >>) 收起 << - United States, North Carolina ... 展开 >> UNC, Lineberger Comprehensive Cancer Center Chapel Hill, North Carolina, United States, 27599 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.31mL

0.66mL

0.33mL

16.54mL

3.31mL

1.65mL

33.07mL

6.61mL

3.31mL

参考文献

[1]Gowri MS, Reaven GM, et al. Effect of masoprocol on glucose transport and lipolysis by isolated rat adipocytes. Metabolism. 1999 Apr;48(4):411-4.

[2]Reed MJ, Meszaros K, et al. Effect of masoprocol on carbohydrate and lipid metabolism in a rat model of Type II diabetes. Diabetologia. 1999 Jan;42(1):102-6.