产品说明书

Benzolamide

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Chemical Structure| 3368-13-6 同义名 : CL11366
CAS号 : 3368-13-6
货号 : A906540
分子式 : C8H8N4O4S3
纯度 : 99%+
分子量 : 320.368
MDL号 : MFCD01750412
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(780.35 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Benzolamide, also known as CL11366, is a potent carbonic anhydrase (CA) inhibitor with Kis values of 15 nM, 9 nM, 94 nM, and 78 nM for hCA I, hCA II, EcoCAγ, and VchCAγ, respectively. Benzolamide also inhibits CAS3 with a Ki value of 54 nM. Benzolamide is used in glaucoma and seizure studies[1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.12mL

0.62mL

0.31mL

15.61mL

3.12mL

1.56mL

31.21mL

6.24mL

3.12mL
参考文献

[1]Prete SD, et, al. Escherichia coli γ-carbonic anhydrase: characterisation and effects of simple aromatic/heterocyclic sulphonamide inhibitors. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1545-1554.

[2]Vullo D, et, al. Sulfonamide Inhibition Studies of the β-Class Carbonic Anhydrase CAS3 from the Filamentous Ascomycete Sordaria macrospora. Molecules. 2020 Feb 25;25(5):1036.

[3]Pospelov AS, et, al. Carbonic anhydrase inhibitors suppress seizures in a rat model of birth asphyxia. Epilepsia. 2021 Jun 27.