产品说明书

YM-750

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Chemical Structure| 138046-43-2 同义名 : -
CAS号 : 138046-43-2
货号 : A901198
分子式 : C31H36N2O
纯度 : 98%
分子量 : 452.63
MDL号 : MFCD00905424
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(231.98 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 YM-750 is a potent ACAT inhibitor with an IC50 value of 0.18 μM. ACAT catalyses the formation of cholesterol esters from cholesterol and long-chain fatty acyl coenzyme A[1][2].In the absence of Cu2+ and in the presence of acLDL, esterified cholesterol accumulates in foam cells for up to 24 hours, and YM-750 inhibits this accumulation[3].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00794209 Healthy Phase 1 Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.21mL

0.44mL

0.22mL

11.05mL

2.21mL

1.10mL

22.09mL

4.42mL

2.21mL
参考文献

[1]Nagata Y, et al. N-[2-[N'-pentyl-(6,6-dimethyl-2,4-heptadiynyl)amino]ethyl]- (2-methyl-1-naphthylthio)acetamide (FY-087). A new acyl coenzyme a:cholesterol acyltransferase (ACAT) inhibitor of diet-induced atherosclerosis formation in mice. Biochem Pharmac

[2]Chang C, et al. Human acyl-CoA:cholesterol acyltransferase (ACAT) and its potential as a target for pharmaceutical intervention against atherosclerosis. Acta Biochim Biophys Sin (Shanghai). 2006;38(3):151-156.

[3]Miike T, et al. Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell-derived foam cells. Life Sci. 2008;82(1-2):79-84.