产品说明书
Theophylline
 |
同义名 : | 1,3-Dimethylxanthine;Theo-24;NSC 2066 |
| CAS号 : | 58-55-9 | |
| 货号 : | A896968 | |
| 分子式 : | C7H8N4O2 | |
| 纯度 : | 98% | |
| 分子量 : | 180.164 | |
| MDL号 : | MFCD00079619 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 10 mg/mL(55.5 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 5 mg/mL(27.75 mM)，配合低频超声助溶 0.1 M NaOH: 20 mg/mL(111.01 mM)，配合低频超声，水浴加热至45℃，并调节pH至10 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Theophylline is a nonselective phosphodiesterase (PDE) inhibitor, adenosine receptor blocker, and histone deacetylase (HDAC) activator. The apparent suppression of airway inflammation by theophylline in asthmatic patients reinforces data from ill vitro experiments, showing inhibitory actions of theophylline on the pro-inflammatory functions of many immune cells[3]. Theophylline has emerged as a major prophylactic agent for controlling the symptoms of chronic asthma, but it provides little if any relief of pulmonary symptoms caused by irreversible chronic airways obstruction[4]. In addition, several studies in patients with COPD (Chronic obstructive pulmonary disease) have shown that theophylline and inhaled beta-agonists interact in an additive fashion, and the combination therapy results in additional objective and subjective improvement over that achieved by either preparation alone[5]. Intravenous theophyllines are a second line treatment for children suffering an acute exacerbation of asthma[6]. In asthma theophyllines should be considered for chronic stable asthma when treatment with optimal doses of inhaled steroids and bronchodilators fails to provide adequate control; for nocturnal asthma; and for prophylaxis and relief of symptoms in children and adults when inhaled treatment cannot be given. In general, theophyllines cannot be recommended for chronic airflow obstruction[7]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
5.55mL 1.11mL 0.56mL |
27.75mL 5.55mL 2.78mL |
55.50mL 11.10mL 5.55mL |
| 参考文献 |
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