Bax inhibitor peptide V5

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Chemical Structure| 579492-81-2 同义名 : BAX Inhibiting Peptide V5;BIP-V5;VPMLK
CAS号 : 579492-81-2
货号 : A879691
分子式 : C27H50N6O6S
纯度 : 99%+
分子量 : 586.788
MDL号 : N/A
存储条件：

Pure form Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(178.94 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(170.42 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor that inhibits a wide range of caspases. Treatment of mouse islets with BIP-V5 (100 μmol/L) upregulated the expressions of anti-apoptotic proteins Bcl-2 and X-linked inhibitor of apoptosis protein by more than 3- and 11-fold, respectively, and downregulated the expressions of Bax, Bad, and nuclear factor-κB-p65 by 10, 30, and nearly 50%, respectively[3]. BIP-V5 at a concentration of 0–50μM reduced STF-cMyc cell death without inducing cell cycle arrest at the G2/M phase[4]. Administration with BIP-V5 (100 μM) also significantly improved islet function following isolation and improved islet graft function following transplantation in streptozotocin-induced diabetic mice[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.70mL

0.34mL

0.17mL

8.52mL

1.70mL

0.85mL

17.04mL

3.41mL

1.70mL
参考文献

[1]Jo MJ, Paek AR, et al. Regulation of cancer cell death by a novel compound, C604, in a c-Myc-overexpressing cellular environment. Eur J Pharmacol. 2015 Dec 15;769:257-65.

[2]Rivas-Carrillo JD, Soto-Gutierrez A, et al. Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice. Diabetes. 2007 May;56(5):1259-67.

[3]Rivas-Carrillo JD, Soto-Gutierrez A, Navarro-Alvarez N, et al. Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice. Diabetes. 2007;56(5):1259-1267.

[4]Jo MJ, Paek AR, Choi JS, et al. Regulation of cancer cell death by a novel compound, C604, in a c-Myc-overexpressing cellular environment. Eur J Pharmacol. 2015;769:257-265.