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ML167

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Chemical Structure| 1285702-20-6 同义名 : NCGC00188654;CID44968231
CAS号 : 1285702-20-6
货号 : A861000
分子式 : C19H17N3O3
纯度 : 99%+
分子量 : 335.357
MDL号 : MFCD27978379
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 16 mg/mL(47.71 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • CLK

    Dyrk1B , IC50:1648 nM

    CLK4, IC50:136 nM
描述 The Cdc2-like kinases (Clk’s) and the dual-specificity tyrosine phosphorylation-regulated kinases (Dyrk’s) have specified roles in gene splicing. ML 167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 values of 136nM, more than 10-fold selectivity against the other family member CLK1/2/3 and DYRK 1A/B[2].
作用机制 ML167 is an ATP-competitive inhibitor[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.98mL

0.60mL

0.30mL

14.91mL

2.98mL

1.49mL

29.82mL

5.96mL

2.98mL
参考文献

[1]Rosenthal AS, Tanega C, et al. An inhibitor of the Cdc2-like kinase 4 (Clk4). 2010 Mar 29 [updated 2011 Mar 3] .

[2]Moyano, P. M. et al. Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic potential. Int. J. Mol. Sci. 2020, 21(20), 7549.

[3]Rosenthal AS, Tanega C, Shen M, Mott BT, Bougie JM, Nguyen DT, Misteli T, Auld DS, Maloney DJ, Thomas CJ. An inhibitor of the Cdc2-like kinase 4 (Clk4). 2010 Mar 29 [updated 2011 Mar 3]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 21735605.