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Aprocitentan

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Chemical Structure| 1103522-45-7 同义名 : Act-132577
CAS号 : 1103522-45-7
货号 : A860741
分子式 : C16H14Br2N6O4S
纯度 : 98%
分子量 : 546.193
MDL号 : MFCD17167076
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(45.77 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ACT-132577 is the major and pharmacologically active metabolite of macitentan), which is dual ETA/ETB endothelin (ET) receptor antagonist designed for tissue targeting.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.83mL

0.37mL

0.18mL

9.15mL

1.83mL

0.92mL

18.31mL

3.66mL

1.83mL
参考文献

[1]Zhang J, Geng P, et al. Pharmacokinetic study of ACT-132577 in rat plasma by ultra performance liquid chromatography-tandem mass spectrometry. Int J Clin Exp Med. 2015 Oct 15;8(10):18420-6.

[2]Iglarz M, Binkert C, et al. Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist. J Pharmacol Exp Ther. 2008 Dec;327(3):736-45.