产品说明书
Fumagillin
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同义名 : | Amebacilin;NSC9168;Fumidil.;Fugillin;Fumagillin, trade name: Fumagilina;Fumidil B |
| CAS号 : | 23110-15-8 | |
| 货号 : | A859732 | |
| 分子式 : | C26H34O7 | |
| 纯度 : | 98%+ | |
| 分子量 : | 458.544 | |
| MDL号 : | MFCD03990453 | |
| 存储条件： |
粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 250 mg/mL(545.2 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Fumagillin is an active amebicide and anti-infective isolated from the fungus Aspergillus fumigatus[3]. Fumagillin, an inhibitor of methionine aminopeptidase-2, causes weight loss by reducing food intake, but with effects on weight that are superior to pair-feeding. Fumagillin engages weight loss-inducing behavioral and physiologic circuits distinct from those activated by simple caloric restriction[4]. Furthermore, fumagillin seems to protect the fungus against phagocytosis in vitro, and during in vivo studies using infection of immunosuppressed mice, a lower fungal burden in the lungs of mice infected with the ∆fmaA mutant[5]. Fumagillin, that is, stimulation of eryptosis, paralleled by Ca(2+) entry, ceramide formation, phosphatidylserine exposure and decrease of cell volume[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.18mL 0.44mL 0.22mL |
10.90mL 2.18mL 1.09mL |
21.81mL 4.36mL 2.18mL |
| 参考文献 |
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