产品说明书

DBPR108

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Chemical Structure| 1186426-66-3 同义名 : -
CAS号 : 1186426-66-3
货号 : A850169
分子式 : C16H25FN4O2
纯度 : 99%+
分子量 : 324.394
MDL号 : MFCD28385883
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(77.07 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 DBPR108 is a highly potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4, with an IC50 of 15 nM. It does not exhibit inhibition on DDP8 and DPP9. The IC50 value remains at 15 nM [1]. DBPR108, a DPP4 inhibitor with an IC50 of 15 nM, exhibits over 3000-fold selectivity against DPP8, DPP9, FAP, and DPP-II. Additionally, the in vivo effects of DBPR108, such as inhibiting plasma DPP-IV activity and suppressing blood glucose elevation, have been demonstrated. As a potential treatment for type 2 diabetes mellitus, DBPR108 is a potent, selective, long-acting, and safe DPP-IV inhibitor.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.08mL

0.62mL

0.31mL

15.41mL

3.08mL

1.54mL

30.83mL

6.17mL

3.08mL
参考文献

[1]Yeh TK, et al. (2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV. Bioorg Med Chem Lett. 2010 Jun