产品说明书

	同义名 :	Cromoglicic acid
	CAS号 :	16110-51-3
	货号 :	A839184
	分子式 :	C23H16O11
	纯度 :	98%
	分子量 :	468.367
	MDL号 :	MFCD00864784
	存储条件：	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Cromolyn is a mast cell stabilizer and is approved for treatment of asthma and for other allergic indications. The direct effect of cromolyn on HMC3 microglia is on cytokines and chemokines production following their activation by the inflammatory cytokine TNF-α. Cromolyn and a new fluorinated analog dramatically reduced the secretion of a wide spectrum of inflammatory mediators, which included cytokines such as IL-1β, IL-6, IL-8 and IFN-γ, and chemokines such as CXCL10, CCL2, CCL3 and CCL4[3]. Cromolyn (100 µM) can effectively inhibit secretion of histamine and PGD(2). Cromolyn also inhibit histamine, leukotrienes and PGD(2) from primary human cord blood-derived cultured mast cells (hCBMCs) stimulated by IgE/Anti-IgE[4]. Cromolyn and nedocromil eliminated voltage-dependent Ca2+ currents, leading to a reduction in depolarization-evoked K+ currents. Cromolyn (but not nedocromil) at high concentrations suppressed Ca2+-dependent Cl- currents triggered by acetylcholine[5]. Moreover, the cromolyn-mediated improvement of intestinal permeability is associated with enhanced pig performance after weaning[6].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.14mL 0.43mL 0.21mL	10.68mL 2.14mL 1.07mL	21.35mL 4.27mL 2.14mL

参考文献

[1]Mereu A, Tedo G, et al. Cromolyn-mediated improvement of intestinal barrier function is associated with enhanced piglet performance after weaning. BMC Vet Res. 2015 Oct 28;11:274. [2]Chang JC, Leung J, et al. Cromolyn ameliorates acute and chronic injury in a rat lung transplant model. J Heart Lung Transplant. 2014 Jul;33(7):749-57. [3]Wang YJ, Monteagudo A, Downey MA, Ashton-Rickardt PG, Elmaleh DR. Cromolyn inhibits the secretion of inflammatory cytokines by human microglia (HMC3). Sci Rep. 2021 Apr 13;11(1):8054 [4]Weng Z, Zhang B, Asadi S, Sismanopoulos N, Butcher A, Fu X, Katsarou-Katsari A, Antoniou C, Theoharides TC. Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. PLoS One. 2012;7(3):e33805 [5]Janssen LJ, Wattie J, Betti PA. Effects of cromolyn and nedocromil on ion currents in canine tracheal smooth muscle. Eur Respir J. 1998 Jul;12(1):50-6 [6]Mereu A, Tedó G, Moeser AJ, Rimbach G, Ipharraguerre IR. Cromolyn-mediated improvement of intestinal barrier function is associated with enhanced piglet performance after weaning. BMC Vet Res. 2015 Oct 28;11:274