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LY2389575 hydrochloride

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Chemical Structure| 885104-09-6 同义名 : -
CAS号 : 885104-09-6
货号 : A828145
分子式 : C15H16BrCl3N4
纯度 : 99%+
分子量 : 438.577
MDL号 : MFCD28133385
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(239.41 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 LY2389575 hydrochloride is a selective and non-competitive mGlu3 negative allosteric modulator (NAM) with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in the level of Mrc1. LY2389575 hydrochloride also independently amplifies the toxicity of amyloid beta (Aβ), which can be used in Alzheimer's disease research[1][2][3].At a concentration of 5 μM, treatment for 1 hour, LY2389575 hydrochloride induces elevated levels of Mrc1 in microglia[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.28mL

0.46mL

0.23mL

11.40mL

2.28mL

1.14mL

22.80mL

4.56mL

2.28mL
参考文献

[1]Caraci F, et al. Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective. Mol Pharmacol. 2011 Mar;79(3):618-26.

[2]Zinni M, et al. mGlu3 receptor regulates microglial cell reactivity in neonatal rats. J Neuroinflammation. 2021 Jan 6;18(1):13.

[3]Srivastava A, et al. Metabotropic Glutamate Receptors in Alzheimer's Disease Synaptic Dysfunction: Therapeutic Opportunities and Hope for the Future. J Alzheimers Dis. 2020;78(4):1345-1361.