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Chlorhexidine

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Chemical Structure| 55-56-1 同义名 : -
CAS号 : 55-56-1
货号 : A814733
分子式 : C22H30Cl2N10
纯度 : 99+%
分子量 : 505.447
MDL号 : MFCD00009673
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(49.46 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Chlorohexidine is cationic bis-biguanide broad spectrum antiseptic with both anti-plaque and antibacterial properties[3]. Topical application of chlorohexidine resulted in a marked reduction of plaque formation, substantial improvement in gingival condition, and considerable decrease in the germ content of the plaque. A significant reduction in oral germ count could be determined in the experimental animals. However, it was not possible to observe a significant inhibition of caries production[4]. Combined use of fluorides and chlorohexidine was seen to exert an inhibitory action on the progress of dental caries[5]. Chlorehexidine (0.2%) and a phenolic mouth rinse significantly reduced plaque growth and gingival inflammation compared to a placebo mouthrinse, however chlorhexidine rinse was more effective against plaque regrowth than the phenolic rinse[6].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03401801 Neuropathic Pain Not Applicable Recruiting February 17, 2019 Korea, Republic of ... 展开 >> Seoul National University Hospital Recruiting Seoul, Korea, Republic of Contact: Jee Youn Moon, M.D.    82-10-5299-2036    jymoon0901@gmail.com    Principal Investigator: Jee Youn Moon, M.D. 收起 <<
NCT02662374 Oral Mucositis Phase 4 Unknown May 2016 -
NCT03161717 Epidural Analgesia Not Applicable Recruiting March 2019 Korea, Republic of ... 展开 >> Korea University Guro Hospital Recruiting Seoul, Korea, Republic of, 08308 Contact: Seung-hoe Song, MBE    82-2-2626-1635    ssessong@korea.ac.kr    Contact: Da-in Lee    82-2-2626-2279    0124dain@gmail.com    Principal Investigator: Sang Sik Choi, MD, PhD          Sub-Investigator: Chung Hun Lee, MD          Sub-Investigator: Mi Kyoung Lee, MD, PhD 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.98mL

0.40mL

0.20mL

9.89mL

1.98mL

0.99mL

19.78mL

3.96mL

1.98mL
参考文献

[1]Sheikh Hasani Y, Paryab M, et al. The Effect of Disinfection with Chlorhexidine on the Shear Bond Strength of Equia Resin-Modified Glass Ionomer Cement to Dentin in Permanent Teeth after Two Thermocycling Protocols. J Dent (Shiraz). 2017 Dec;18(4):265-271.

[2]Strain GM. Chlorhexidine. J Small Anim Pract. 2017 Nov 28.

[3]Prasad KA, John S, Deepika V, Dwijendra KS, Reddy BR, Chincholi S. Anti-Plaque Efficacy of Herbal and 0.2% Chlorhexidine Gluconate Mouthwash: A Comparative Study. J Int Oral Health. 2015;7(8):98‐102

[4]Treide A, Klimm W, Morosova L. Klinische und tierexperimentelle Untersuchungen üben den Einfluss lokalapplizierten Chlorhexidins auf Plaquebildung, Keimflora und Kariesbefall [Clinical and experimental animal studies made to determine the influence of topically applied chlorohexidine upon plaque formation, germ flora, and caries production (author's transl)]. Zahn Mund Kieferheilkd Zentralbl. 1980;68(2):106‐115

[5]Novikov LL, Treide A, Kolesnik AG, Stösser L, Schaper R. Der Einfluss anorganischer und organischer Fluoride in Kombination mit Molybdän und Chlorhexidin auf Stoffwechselprozesse, Fluoridgehalt und Kariesbefall der Zähne von Wistarratten [Effects of inorganic and organic fluorides combined with molybdenum and chlorohexidine upon processes of metabolism, fluoride content, and cariosity of the teeth of Wistar rats (author's transl)]. Zahn Mund Kieferheilkd Zentralbl. 1980;68(1):3‐8

[6]Goutham BS, Manchanda K, Sarkar AD, Prakash R, Jha K, Mohammed S. Efficacy of two commercially available Oral Rinses - Chlorohexidine and Listrine on Plaque and Gingivitis - A Comparative Study. J Int Oral Health. 2013;5(4):56‐61