Vancomycin hydrochloride
产品说明书
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同义名 : | Vancomycin (hydrochloride);Vancomycin HCl;Lyphocin |
| CAS号 : | 1404-93-9 | |
| 货号 : | A810922 | |
| 分子式 : | C66H76Cl3N9O24 | |
| 纯度 : | ≥900ug/mg | |
| 分子量 : | 1485.715 | |
| MDL号 : | MFCD03613611 | |
| 存储条件： |
Pure form Inert atmosphere,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 20 mg/mL(13.46 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 30 mg/mL(20.19 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Vancomycin hydrochloride is an antibiotic for the treatment of bacterial infections. It acts by inhibiting the second stage of cell wall synthesis of susceptible bacteria and also alters the permeability of the cell membrane and selectively inhibits ribonucleic acid synthesis. It is a large glycopeptide compound with a molecular weight of 1450 Da[3]. in vivo, vancomycin hydrochloride is administered intravenously, with a standard infusion time of at least 1 h. In patients with normal creatinine clearance, vancomycin has an α-distribution phase of ∼30 min to 1 h and a β-elimination half-life of 6 - 12 h. The volume of distribution is 0.4 - 1 L/kg. The binding of vancomycin to protein has been reported in the literature to range from 10% to 50%[3]. in vitro, vancomycin is active against a large number of species of gram-positive bacteria, such as staphylococcus aureus, staph[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
0.67mL 0.13mL 0.07mL |
3.37mL 0.67mL 0.34mL |
6.73mL 1.35mL 0.67mL |
| 参考文献 |
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