Astragaloside II
产品说明书
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同义名 : | Astrasieversianin VIII |
| CAS号 : | 84676-89-1 | |
| 货号 : | A804627 | |
| 分子式 : | C43H70O15 | |
| 纯度 : | 98% | |
| 分子量 : | 827.007 | |
| MDL号 : | MFCD12546127 | |
| 存储条件： |
Pure form Keep in dark place,Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 145 mg/mL(175.33 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Astragaloside II (AS II), a novel saponin purified from Astragalus membranes, can modulate the immune response, repair tissue injury, and prevent inflammatory response. AS II (3.2 and 6.4 mg·kg-1·d-1) ameliorated podocyte injury and mitochondrial dysfunction in diabetic rats partly through regulation of Nrf2 and PINK1 pathway[3]. AS II could alleviate inflammatory response in LPS-induced CCD-18Co cells and in DSS(dextran sulfate sodium)-induced UC (Ulcerative colitis) in mice[4]. Astragaloside II (10 and 30 nmol/L) significantly enhanced the proliferation of primary splenocytes induced by ConA, alloantigen or anti-CD3. Astragaloside II (30 nmol/L) significantly increased IL-2 and IFN-γ secretion, upregulated the mRNA levels of IFN-γ a nd T-bet in primary splenocytes, and promoted CD25 and CD69 expression on primary CD4(+) T cells upon TCR stimulation. Furthermore, astragaloside II (100 nmol/L) promoted CD45-mediated dephosphorylation of LCK (Tyr505) in primary T cells, which could be blocked by a specific CD45 PTPase inhibitor[5]. AS II promoted wound closure and increased cell proliferation, L-arginine uptake, CAT1 and CAT2 protein levels, total protein synthesis, and phosphorylation of mTOR, S6K, and 4E-BP1 in Caco-2 cells[6]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.21mL 0.24mL 0.12mL |
6.05mL 1.21mL 0.60mL |
12.09mL 2.42mL 1.21mL |
| 参考文献 |
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