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CMPD1

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Chemical Structure| 41179-33-3 同义名 : MK2a Inhibitor
CAS号 : 41179-33-3
货号 : A784195
分子式 : C22H20FNO2
纯度 : 97%
分子量 : 349.398
MDL号 : MFCD08703098
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(300.52 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 CMPD1 is a selective, non-ATP-competitive inhibitor of p38 MAPK-mediated MK2 phosphorylation with a Kiapp of 330 nM[1][2].CMPD1 does not inhibit p38 MAPK-mediated phosphorylation of the other two substrates (MBP and ATF2). CMPD1 induces mitotic arrest and apoptosis in U87 cells[1].CMPD1 inhibits microtubule protein polymerisation in glioblastoma cells[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.86mL

0.57mL

0.29mL

14.31mL

2.86mL

1.43mL

28.62mL

5.72mL

2.86mL
参考文献

[1]Gurgis F, et al. Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2. Cell Death Discov. 2015 Sep 7;1:15028.

[2]Davidson W, er al. Discovery and characterization of a substrate selective p38alpha inhibitor. Biochemistry. 2004 Sep 21;43(37):11658-71.

[3]Phoa AF, et al. Pharmacology of novel small-molecule tubulin inhibitors in glioblastoma cells with enhanced EGFR signalling. Biochem Pharmacol. 2015 Dec 15;98(4):587-601.