产品说明书
Calmidazolium chloride
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同义名 : | R 24571;Calmidazolium (chloride) |
| CAS号 : | 57265-65-3 | |
| 货号 : | A784014 | |
| 分子式 : | C31H23Cl7N2O | |
| 纯度 : | 99%+ | |
| 分子量 : | 687.698 | |
| MDL号 : | MFCD00077679 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(152.68 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Calmidazolium chloride is a calmodulin antagonist that antagonises CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+ transporter ATPase, with IC50 values of 0.15 and 0.35 μM, respectively[1] .Calmidazolium chloride has also been used in anticancer studies[2] .Calmidazolium chloride binds calmodulin with a Kd of 3 nM[3] .Calmidazolium chloride also induces apoptosis in some cancer cell lines. Calmidazolium chloride inhibited the growth of mouse F9 ECC at concentrations of 3, 5, 7, and 10 μM for 30 min-24 h[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.45mL 0.29mL 0.15mL |
7.27mL 1.45mL 0.73mL |
14.54mL 2.91mL 1.45mL |
| 参考文献 |
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