Trolox
产品说明书
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同义名 : | 6-hydroxy-2,5,7,8-tetramethylchroman-2-Carboxylic Acid |
| CAS号 : | 53188-07-1 | |
| 货号 : | A783985 | |
| 分子式 : | C14H18O4 | |
| 纯度 : | 95% | |
| 分子量 : | 250.29 | |
| MDL号 : | MFCD00006846 | |
| 存储条件： |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(419.51 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Trolox is a water-soluble analogue of vitamin E with a powerful antioxidant effect. In a canine model of two hours of left anterior descending coronary artery occlusion followed by four hours of reperfusion, Trolox and ascorbic acid reduced the area of infarction within the area at risk. Trolox has shown to protect mammalian cells from oxidative damage[1]. Trolox could prevent oxidative stress-induced apoptosis in thymocytes. Pre- or posttreatment of cells with Trolox reduced H2O2-induced DNA fragmentation to control levels and below[2]. Trolox prolonged substantially the survival of human ventricular myocytes and hepatocyte against oxyradicals generated with xanthine oxidase plus hypoxanthine, and prevented lysis of red cells exposed to an azo-initiator (2,2'-azo-bis(2-amidinopropane) HCl). In each cell type, the protection by Trolox was dose dependent and surpassed those given by such water-soluble antioxidants as ascorbic acid, superoxide dismutase, and (or) catalase, each examined at or near its optimal level in the same system[3]. Trolox treatment in BDL (bile duct ligation) rats prevented the increase in ALT(Alanine aminotransferase). Collagen was increased by chronic BDL, but trolox administration preserved the normal collagen concentration[4]. Trolox prevents osteoclast formation and bone loss by inhibiting both RANKL induction in osteoblasts and c-Fos expression in osteoclast precursors[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.00mL 0.80mL 0.40mL |
19.98mL 4.00mL 2.00mL |
39.95mL 7.99mL 4.00mL |
| 参考文献 |
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