Echinatin

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Chemical Structure| 34221-41-5 同义名 : -
CAS号 : 34221-41-5
货号 : A783726
分子式 : C16H14O4
纯度 : 95%
分子量 : 270.28
MDL号 : MFCD00075719
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(443.98 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Echinatin is a chalcone isolated from the Chinese herbal medicine Gancao with hepatoprotective and anti-inflammatory effects[3]. Administration of echinatin obviously inhibits NLRP3 inflammasome activation and ameliorates LPS-induced septic shock and dextran sodium sulfate-induced (DSS-induced) colitis in mice. Moreover, echinatin exerted favorable pharmacological effects on liver inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis (NASH)[4]. Echinatin induced apoptosis and autophagy through inactivation of AKT/mTOR signaling pathway, whereas constitutive activation of AKT significantly abrogated these effects. Furthermore, echinatin had a significant antitumor effect in the tumor xenograft model and markedly suppressed cell migration and invasion abilities of ESCC (Esophageal squamous cell carcinoma) cells in a dose-dependent manner[5]. Echinatin exerted its protective effect against MI/R (myocardial ischemic/reperfusion) injury at least partially by suppressing the Hippo/YAP signaling pathway[6]. Echinatin mitigates H2O2-induced oxidative damage and apoptosis in HLECs (Human lens epithelial B3 cells) via the Nrf2/HO-1 pathway, suggesting that Ech may be a potential drug for the treatment of cataracts[7].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.70mL

0.74mL

0.37mL

18.50mL

3.70mL

1.85mL

37.00mL

7.40mL

3.70mL
参考文献

[1]Fu Y, Chen J, et al. Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice. Food Chem. 2013 Nov 15;141(2):1063-71.

[2]Inoue B, Inaba K, et al. The effects of echinatin and its related compounds on the mitochondrial energy transfer reaction. J Toxicol Sci. 1982 Nov;7(4):245-54.

[3]Liang M, Li X, Ouyang X, Xie H, Chen D. Antioxidant Mechanisms of Echinatin and Licochalcone A. Molecules. 2018 Dec 20;24(1):3

[4]Xu G, Fu S, Zhan X, Wang Z, Zhang P, Shi W, Qin N, Chen Y, Wang C, Niu M, Guo Y, Wang J, Bai Z, Xiao X. Echinatin effectively protects against NLRP3 inflammasome-driven diseases by targeting HSP90. JCI Insight. 2021 Jan 25;6(2):e134601

[5]Hong P, Liu QW, Xie Y, Zhang QH, Liao L, He QY, Li B, Xu WW. Echinatin suppresses esophageal cancer tumor growth and invasion through inducing AKT/mTOR-dependent autophagy and apoptosis. Cell Death Dis. 2020 Jul 13;11(7):524

[6]Niu J, Li Y, Song X, Liu Y, Li Y, Li Y. Cardioprotective Effect of Echinatin Against Ischemia/Reperfusion Injury: Involvement of Hippo/Yes-Associated Protein Signaling. Front Pharmacol. 2021 Jan 11;11:593225

[7]Ran H, Liu H, Wu P. Echinatin mitigates H2O2-induced oxidative damage and apoptosis in lens epithelial cells via the Nrf2/HO-1 pathway. Adv Clin Exp Med. 2021 Nov;30(11):1195-1203