Trigonelline HCl

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Chemical Structure| 6138-41-6 同义名 : 胡芦巴碱盐酸盐 ;Trigonelline Hydrochloride;Trigonelline chloride;N-methyl Nicotinic Acid Betaine;Trigonelline (chloride);Gynesine Hydrochloride;Coffearine Hydrochloride;Nicotinic acid N-methylbetaine Hydrochloride
CAS号 : 6138-41-6
货号 : A764743
分子式 : C7H8ClNO2
纯度 : 99%+
分子量 : 173.597
MDL号 : MFCD00077250
存储条件：

Pure form Inert atmosphere,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 20 mg/mL(115.21 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(576.05 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Trigonelline Hydrochloride, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. Trigonelline increased body weight, inhibited the kidney weight/body weight ratio and blood glucose levels, and reduced the levels of blood urea nitrogen, creatinine and albumin in type 2 diabetic rats. In addition, trigonelline also reduced inflammation, oxidative stress and kidney cell apoptosis in T2DM rats[1]. Trigonelline has anti-inflammatory, anti-oxidant, and anti-pathogenic effects. 50 μM of trigonelline had the best anti-aging activity and could prolong the lifespan of Caenorhabditis elegans (C. elegans) by about 17.9%. Trigonelline can enhance the oxidative, heat, and pathogenic stress resistance of C. elegans. Trigonelline could also delay the development of neurodegenerative diseases, such as AD, PD, and HD, in models of C. elegans[2]. Administering the NRF2 inhibitor trigonelline hydrochloride to infected BALB/c mice resulted in reduced HO-1 (heme oxygenase 1) and ATF3 expression, decreased spleen and liver parasite burdens, and increased proinflammatory cytokine levels[3]. Trigonelline has the inhibitory effect on activated bone marrow-derived mast cells (BMMCs) and verified its anti-inflammatory properties using an ovalbumin (OVA)-induced asthma model. Trigonelline suppressed BMMC degranulation and decreased the production of the cytokines, prostaglandin D2 (PGD2) and leukotriene C4 (LTC4) in a dose-dependent manner[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.76mL

1.15mL

0.58mL

28.80mL

5.76mL

2.88mL

57.60mL

11.52mL

5.76mL
参考文献

[1]Li Y, Li Q, Wang C, Lou Z, Li Q. Trigonelline reduced diabetic nephropathy and insulin resistance in type 2 diabetic rats through peroxisome proliferator-activated receptor-γ. Exp Ther Med. 2019 Aug;18(2):1331-1337

[2]Zeng WY, Tan L, Han C, Zheng ZY, Wu GS, Luo HR, Li SL. Trigonelline Extends the Lifespan of C. Elegans and Delays the Progression of Age-Related Diseases by Activating AMPK, DAF-16, and HSF-1. Oxid Med Cell Longev. 2021 Sep 25;2021:7656834

[3]Saha S, Roy S, Dutta A, Jana K, Ukil A. Leishmania donovani Targets Host Transcription Factor NRF2 To Activate Antioxidant Enzyme HO-1 and Transcriptional Repressor ATF3 for Establishing Infection. Infect Immun. 2021 Jun 16;89(7):e0076420

[4]Zhang W, Zhang Y, Chen S, Zhang H, Yuan M, Xiao L, Lu Y, Xu H. Trigonelline, An Alkaloid From Leonurus japonicus Houtt., Suppresses Mast Cell Activation and OVA-Induced Allergic Asthma. Front Pharmacol. 2021 Aug 4;12:687970