产品说明书

Evenamide

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Chemical Structure| 1092977-61-1 同义名 : NW-3509
CAS号 : 1092977-61-1
货号 : A748019
分子式 : C16H26N2O2
纯度 : 97%
分子量 : 278.39
MDL号 : MFCD28502433
存储条件:

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(377.17 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Evenamide (NW-3509) emerges as an orally active blocker of voltage-gated sodium channels (VGSCs), with a Ki of 0.4 µM, tailored for schizophrenia research. Its effectiveness spans across a wide array of rodent models for psychosis, mania, depression, and aggressiveness[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.59mL

0.72mL

0.36mL

17.96mL

3.59mL

1.80mL

35.92mL

7.18mL

3.59mL

参考文献

[1]Valentina Zuliani, et al. Advances in Design and Development of Sodium Channel Blockers. Ion Channels and Their Inhibitors pp 79-115.

[2]Faravelli, et al. P.3.f.022 Evenamide (formerly NW-3509) targets new mechanisms, and represents a new approach to the management of untreated symptoms in schizophrenia.