VU0422288

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Chemical Structure| 1630936-95-6 同义名 : ML396
CAS号 : 1630936-95-6
货号 : A739334
分子式 : C17H11Cl2N3O2
纯度 : 99%+
分子量 : 360.194
MDL号 : MFCD28411626
存储条件：

Pure form Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(69.41 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 VU0422288, also known as ML396, is a positive allosteric modulator of class III mGluRs. In a calcium mobilisation assay, the EC50 values of VU0422288 on mGluR4, mGluR7 and mGluR8 were 125 nM, 146 nM and 108 nM, respectively. VU0422288 reversed deficits in contextual fear memory, social recognition, and apnoea in a Rett syndrome (RTT) model of mice[1][2].Acting at a concentration of 1 μM for 5 min, VU0422288 enhanced the LSP4-2022 (30 μM)-induced reduction in the slope of field excitatory postsynaptic potentials (fEPSPs) in hippocampal coronal slices[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.78mL

0.56mL

0.28mL

13.88mL

2.78mL

1.39mL

27.76mL

5.55mL

2.78mL
参考文献

[1]Jalan-Sakrikar N, et al. Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem Neurosci. 2014 Dec 17;5(12):1221-37.

[2]Gogliotti RG, et al. mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome. Sci Transl Med. 2017 Aug 16;9(403):eaai7459.