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BQR-695

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Chemical Structure| 1513879-21-4 同义名 : NVP-BQR695
CAS号 : 1513879-21-4
货号 : A725053
分子式 : C19H20N4O3
纯度 : 99%+
分子量 : 352.387
MDL号 : MFCD30533463
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(141.89 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Furthermore, treatment with 0.5 μM of either KAI407 or BQR695 leads to the redistribution of GFP-PHOsh2 to the plasma membrane of parasites, aligning with the depletion of intracellular PI4P upon inhibition of PfPI4K function. BQR695, in particular, demonstrates no toxicity against mature red blood cells (RBCs), induces a schizont-stage arrest similar to that observed with imidazopyrazine-treated parasites, and exhibits cross-resistance with imidazopyrazine-resistant lines[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.84mL

0.57mL

0.28mL

14.19mL

2.84mL

1.42mL

28.38mL

5.68mL

2.84mL
参考文献

[1]McNamara CW, et al. Targeting Plasmodium PI(4)K to eliminate malaria. Nature. 2013 Dec 12;504(7479):248-253.