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Evocalcet

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Chemical Structure| 870964-67-3 同义名 : KHK7580;MT-4580
CAS号 : 870964-67-3
货号 : A725008
分子式 : C24H26N2O2
纯度 : 99%+
分子量 : 374.476
MDL号 : MFCD30533424
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(80.11 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Evocalcet (KHK7580) functions as an orally administered agonist for the calcium-sensing receptor (CaSR), effectively suppressing the secretion of parathyroid hormone (PTH) from parathyroid gland cells. This characteristic makes Evocalcet a valuable agent for hyperparathyroidism research[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.67mL

0.53mL

0.27mL

13.35mL

2.67mL

1.34mL

26.70mL

5.34mL

2.67mL
参考文献

[1]Sakai M, et al. Evocalcet prevents ectopic calcification and parathyroid hyperplasia in rats with secondary hyperparathyroidism. PLoS One. 2020 Apr 28;15(4):e0232428.

[2]Kawata T, et al. A novel calcimimetic agent, evocalcet (MT-4580/KHK7580), suppresses the parathyroid cell function with little effect on the gastrointestinal tract or CYP isozymes in vivo and in vitro. PLoS One. 2018 Apr 3;13(4):e0195316.