AZD5904

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Chemical Structure| 618913-30-7 同义名 : -
CAS号 : 618913-30-7
货号 : A724557
分子式 : C10H12N4O2S
纯度 : 99%+
分子量 : 252.293
MDL号 : MFCD31619279
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(198.18 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Myeloperoxidase (MPO) is a peroxidase enzyme that acts as a key regulator of oxidative stress-mediated apoptosis in cells. AZD5904 is an irreversible MPO inhibitor with similar potency in human (IC50 = 140 nM), rats, and mice. In isolated human neutrophils, AZD5904 at a concentration of 1 μM inhibited PMA-stimulated HOCl by over 90%. Rats with a plasma content of AZD5904 at around 5 μM showed decreased in vivo formation of glutathione sulphonamide from in situ zymosan activated peritoneum neutrophils. AZD5904 has low CNS penetration[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.96mL

0.79mL

0.40mL

19.82mL

3.96mL

1.98mL

39.64mL

7.93mL

3.96mL
参考文献

[1]AZD5904