2-HBA

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Chemical Structure| 131359-24-5 同义名 : Bis(2-hydroxybenzylidene)acetone
CAS号 : 131359-24-5
货号 : A724295
分子式 : C17H14O3
纯度 : 99%
分子量 : 266.29
MDL号 : MFCD01790784
存储条件：

Pure form Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(394.31 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Induction of phase 2 response is a powerful and highly efficient strategy for protection against the continual damaging effects of reactive oxygen intermediates and electrophiles, both of which participate in the pathogenesis of cancer and many other chronic diseases. NAD(P)H-quinone acceptor oxidoreductase 1 (NQO1), a Phase 2 enzyme, catalyzes diverse reactions that collectively result in broad protection against electrophiles and oxidant[1]. 2-HBA (Bis(2-hydroxybenzylidene)acetone), a curcumin analog, induced NQO1 in a concentration-dependent manner with a CD value of 0.15 mM. Treatment with 2-HBA caused cell cycle arrest and apoptosis (caspase-3 and caspase-10) in both murine leukemia cell line L1210 wild type cells and their Y8 drug-resistant counterparts in a concentration-dependent manner[2]. Also, 2-HBA at 0.25 – 4 μM dose-dependently induced the Nrf2 signaling pathway in HBE cells by blocking ubiquitylation. In A/J mice with lung adenocarcinoma, intraperitoneal injections of BHBA (20 mg/kg) twice over a 3-day period reduced the internal tumor number to nearly 50% compared with the corn oil control [3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.76mL

0.75mL

0.38mL

18.78mL

3.76mL

1.88mL

37.55mL

7.51mL

3.76mL
参考文献

[1]Dinkova-Kostova AT, Fahey JW, Wade KL, et al. Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts. Cancer Epidemiol Biomarkers Prev. 2007;16(4):847‐851.

[2]Dinkova-Kostova AT, Cory AH, Bozak RE, Hicks RJ, Cory JG. Bis(2-hydroxybenzylidene)acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway. Cancer Lett. 2007;245(1-2):341-9

[3]Shen T, Jiang T, Long M, et al. A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Response. Antioxid Redox Signal. 2015;23(8):651‐664.