产品说明书
Heparan Sulfate
 |
同义名 : | 硫酸类肝素 ;HS;Alpha-idosane;Tavidan;Suleparoid;N-Acetylheparan Sulfate;HHS 5;Heparitin sulfate |
| CAS号 : | 9050-30-0 | |
| 货号 : | A724029 | |
| 分子式 : | C26H36N3O39S6 | |
| 纯度 : | >50.0 IU/mg | |
| 分子量 : | 1206.95 | |
| MDL号 : | N/A | |
| 存储条件： |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
H2O: 100 mg/mL(82.85 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Heparan Sulfate is a linear polysaccharide belonging to the glycosaminoglycan family.Heparan Sulfate consists of glucuronic acid and iduronic acid residues, as well as N-acetyl glucosamines with a variety of sulfation modifications, and is typically 50-200 disaccharides in length. Heparan Sulfate interacts with a variety of proteins, including growth factors, morphogens, and adhesion molecules to regulate important developmental processes in both invertebrates and vertebrates.Heparan Sulfate acts as a cofactor to regulate developmental signalling through a variety of mechanisms including, but not limited to, the maintenance of morphogen gradients and co-receptor function[1].Heparan Sulfate proteoglycans act as receptors for proteases and protease inhibitors, modulating their spatial distribution and activity.Membrane Heparan sulfate proteoglycans act as co-receptors for a variety of tyrosine kinase-type growth factor receptors, lowering their activation thresholds or altering the duration of the signalling response [2].Heparan Sulfate affects the binding affinity of intestinal epithelial cells for Wnt, thereby promoting the activation of classical Wnt signalling and the regeneration of small intestinal crypts after epithelial injury [3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
0.83mL 0.17mL 0.08mL |
4.14mL 0.83mL 0.41mL |
8.29mL 1.66mL 0.83mL |
| 参考文献 |
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