产品说明书

HPMC

Print
Chemical Structure| 9004-65-3 同义名 : 羟丙甲纤维素 ;Hypromellose;(Hydroxypropyl)methyl cellulose;Celacol HPM 5000
CAS号 : 9004-65-3
货号 : A720586
分子式 : C3H8O2.xCH4O.xUnspecified
纯度 : viscosity 2600-5600m.Pas, 2 % in H2O
分子量 : 0
MDL号 : MFCD00131360
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 10 mg/mL，配合低频超声助溶
动物实验配方：
生物活性
描述 Hypromellose, also known as hydroxypropylmethylcellulose, enhances drug delivery by controlling the drug's release rate, thereby extending its therapeutic effects[1]. This polymer has been employed in sustained-release pharmaceutical formulations for many years. In the manufacturing of matrix tablets, hypromellose absorbs water upon contact, forming a viscous gel barrier around and within the tablet. Factors influencing drug release through hypromellose include the water diffusion rate into the dry polymer, the speed of gelation, the viscosity of the gel, and the rate at which the hypromellose gel erodes[2].
参考文献

[1]Li CL, et al. The use of hypromellose in oral drug delivery. J Pharm Pharmacol. 2005 May;57(5):533-46.

[2]Braund R, et al. Hypromellose films for the delivery of growth factors for wound healing.

[3]Capita L, et al. Prospective evaluation of hypromellose 2% for punctal occlusion in patients with dry eye. Cornea. 2015 Feb;34(2):188-92.

[4]Ban SJ, et al. Antihyperglycemic and antioxidative effects of Hydroxyethyl Methylcellulose (HEMC) and Hydroxypropyl Methylcellulose (HPMC) in mice fed with a high fat diet. Int J Mol Sci. 2012;13(3):3738-50.