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ST271

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Chemical Structure| 106392-48-7 同义名 : -
CAS号 : 106392-48-7
货号 : A709920
分子式 : C16H20N2O2
纯度 : 99%+
分子量 : 272.342
MDL号 : MFCD31544351
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(183.59 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ST271 is a potent inhibitor of protein tyrosine kinase (PTK) with IC50s of 6.7μM, also inhibits phospholipase D activation with IC50 of 9 μM. ST271 did not inhibit Ins(1,4,5)P3 generation, but did inhibit protein tyrosine phosphorylation stimulated by fMet-Leu-Phe. ST271 does not inhibit phorbol ester-stimulated PLD, indicating that it does not inhibit PLD per se, but probably acts at a site between the receptor and the phospholipase[1]. PLD was activated in response to 0.3 U/ml thrombin, and this activation was reduced by several of the PTK inhibitor ST271. ST271 partially inhibited peptide phosphorylation in the membrane preparation and in permeabilized platelets[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.67mL

0.73mL

0.37mL

18.36mL

3.67mL

1.84mL

36.72mL

7.34mL

3.67mL
参考文献

[1]Uings IJ, Thompson NT, Randall RW, Spacey GD, Bonser RW, Hudson AT, Garland LG. Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil. Biochem J. 1992 Feb 1;281 ( Pt 3)(Pt 3):597-600. doi: 10.1042/bj2810597. Erratum in: Biochem J 1992 May 1;283(Pt 3):919. PMID: 1371383; PMCID: PMC1130730.

[2]Martinson EA, Scheible S, Presek P. Inhibition of phospholipase D of human platelets by protein tyrosine kinase inhibitors. Cell Mol Biol (Noisy-le-grand). 1994 Jul;40(5):627-34. PMID: 7526916.